The Multiple Localized Glyceraldehyde-3-Phosphate Dehydrogenase Contributes to the Attenuation of the Francisella tularensis dsbA Deletion Mutant

The Multiple Localized Glyceraldehyde-3-Phosphate Dehydrogenase Contributes to the Attenuation of the Francisella tularensis dsbA Deletion Mutant

The DsbA homolog of Francisella tularensis was previously demonstrated to be required for intracellular replication and animal death. Disruption of the dsbA gene leads to a pleiotropic phenotype that could indirectly affect a number of different cellular pathways. To reveal the broad effects of DsbA...

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Bibliographic Details
Main Authors: Ivona Pavkova, Monika Kopeckova, Jana Klimentova, Monika Schmidt, Valeria Sheshko, Margarita Sobol, Jitka Zakova, Pavel Hozak, Jiri Stulik
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
DsbA
SILAC
glyceraldehyde-3-phosphate dehydrogenase
Francisella tularensis
moonlighting
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00503/full

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http://journal.frontiersin.org/article/10.3389/fcimb.2017.00503/full

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