8-Triazolylpurines: Towards Fluorescent Inhibitors of the MDM2/p53 Interaction.

8-Triazolylpurines: Towards Fluorescent Inhibitors of the MDM2/p53 Interaction.

Small molecule nonpeptidic mimics of α-helices are widely recognised as protein-protein interaction (PPIs) inhibitors. Protein-protein interactions mediate virtually all important regulatory pathways in a cell, and the ability to control and modulate PPIs is therefore of great significance to basic...

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Bibliographic Details
Main Authors: Mariell Pettersson, David Bliman, Jimmy Jacobsson, Jesper R Nilsson, Jaeki Min, Luigi Iconaru, R Kiplin Guy, Richard W Kriwacki, Joakim Andréasson, Morten Grøtli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4420247?pdf=render

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http://europepmc.org/articles/PMC4420247?pdf=render

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