Activation of the Hedgehog signaling pathway leads to fibrosis in aortic valves

Activation of the Hedgehog signaling pathway leads to fibrosis in aortic valves

Abstract Background Fibrosis is a pathological wound healing process characterized by excessive extracellular matrix deposition, which interferes with normal organ function and contributes to ~ 45% of human mortality. Fibrosis develops in response to chronic injury in nearly all organs, but the a ca...

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Bibliographic Details
Main Authors: Dongsheng Gu, Arvin H. Soepriatna, Wenjun Zhang, Jun Li, Jenny Zhao, Xiaoli Zhang, Xianhong Shu, Yongshi Wang, Benjamin J. Landis, Craig J. Goergen, Jingwu Xie
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Cell & Bioscience
Subjects:
Aortic valve
Smoothened
Hedgehog
Fibrosis
Stenosis
Online Access:https://doi.org/10.1186/s13578-023-00980-1

Internet

https://doi.org/10.1186/s13578-023-00980-1

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