Quantitative glycoproteomics analysis identifies novel FUT8 targets and signaling networks critical for breast cancer cell invasiveness

Quantitative glycoproteomics analysis identifies novel FUT8 targets and signaling networks critical for breast cancer cell invasiveness

Abstract Background We recently showed that fucosyltransferase 8 (FUT8)-mediated core fucosylation of transforming growth factor-β receptor enhances its signaling and promotes breast cancer invasion and metastasis. However, the complete FUT8 target glycoproteins and their downstream signaling networ...

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Bibliographic Details
Main Authors: Cheng-Fen Tu, Fu-An Li, Ling-Hui Li, Ruey-Bing Yang
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Core fucosylation
FUT8
Glycoproteomics
Metastasis
Online Access:https://doi.org/10.1186/s13058-022-01513-3

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