Probing the effect of clustering on EphA2 receptor signaling efficiency by subcellular control of ligand-receptor mobility

Probing the effect of clustering on EphA2 receptor signaling efficiency by subcellular control of ligand-receptor mobility

Clustering of ligand:receptor complexes on the cell membrane is widely presumed to have functional consequences for subsequent signal transduction. However, it is experimentally challenging to selectively manipulate receptor clustering without altering other biochemical aspects of the cellular syste...

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Bibliographic Details
Main Authors: Zhongwen Chen, Dongmyung Oh, Kabir Hassan Biswas, Ronen Zaidel-Bar, Jay T Groves
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
EphA2
micropattern
single molecule imaging
receptor clustering
supported membrane
phase separation
Online Access:https://elifesciences.org/articles/67379

Internet

https://elifesciences.org/articles/67379

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