Probing the effect of clustering on EphA2 receptor signaling efficiency by subcellular control of ligand-receptor mobility
Clustering of ligand:receptor complexes on the cell membrane is widely presumed to have functional consequences for subsequent signal transduction. However, it is experimentally challenging to selectively manipulate receptor clustering without altering other biochemical aspects of the cellular syste...
Main Authors: | Zhongwen Chen, Dongmyung Oh, Kabir Hassan Biswas, Ronen Zaidel-Bar, Jay T Groves |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-08-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/67379 |
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