New Derivatives of the Multi-Stage Active Malaria Box Compound MMV030666 and Their Antiplasmodial Potencies

New Derivatives of the Multi-Stage Active Malaria Box Compound MMV030666 and Their Antiplasmodial Potencies

MMV’s Malaria Box compound MMV030666 shows multi-stage activity against various strains of <i>Plasmodium falciparum</i> and lacks resistance development. To evaluate the importance of its diarylether partial structure, diarylthioethers and diphenylamines with varying substitution pattern...

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Bibliographic Details
Main Authors: Theresa Hermann, Robin Wallner, Johanna Dolensky, Werner Seebacher, Eva-Maria Pferschy-Wenzig, Marcel Kaiser, Pascal Mäser, Robert Weis
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceuticals
Subjects:
malaria
MMV
<i>Plasmodium falciparum</i>
cytotoxicity
PAMPA
Online Access:https://www.mdpi.com/1424-8247/15/12/1503

Internet

https://www.mdpi.com/1424-8247/15/12/1503

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