Amino acid homeostasis is a target of metformin therapy

Amino acid homeostasis is a target of metformin therapy

Objective: Unexplained changes in regulation of branched chain amino acids (BCAA) during diabetes therapy with metformin have been known for years. Here we have investigated mechanisms underlying this effect. Methods: We used cellular approaches, including single gene/protein measurements, as well a...

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Main Authors: Calum Forteath, Ify Mordi, Raid Nisr, Erika J. Gutierrez-Lara, Noor Alqurashi, Iain R. Phair, Amy R. Cameron, Craig Beall, Ibrahim Bahr, Mohapradeep Mohan, Aaron K.F. Wong, Adel Dihoum, Anwar Mohammad, Colin N.A. Palmer, Douglas Lamont, Kei Sakamoto, Benoit Viollet, Marc Foretz, Chim C. Lang, Graham Rena
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Molecular Metabolism
Subjects:
Metformin
Branched chain amino acids
mTOR
SNAT2
Glutamine
Rapamycin
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877823000844

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http://www.sciencedirect.com/science/article/pii/S2212877823000844

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