Boron Delivery to Brain Cells via Cerebrospinal Fluid (CSF) Circulation in BNCT of Brain-Tumor-Model Rats—Ex Vivo Imaging of BPA Using MALDI Mass Spectrometry Imaging

Boron Delivery to Brain Cells via Cerebrospinal Fluid (CSF) Circulation in BNCT of Brain-Tumor-Model Rats—Ex Vivo Imaging of BPA Using MALDI Mass Spectrometry Imaging

The blood–brain barrier (BBB) is likely to be intact during the early stages of brain metastatic melanoma development, and thereby inhibits sufficient drug delivery into the metastatic lesions. Our laboratory has been developing a system for boron drug delivery to brain cells via cerebrospinal fluid...

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Bibliographic Details
Main Authors: Sachie Kusaka, Yumi Miyake, Yugo Tokumaru, Yuri Morizane, Shingo Tamaki, Yoko Akiyama, Fuminobu Sato, Isao Murata
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Life
Subjects:
boron neutron capture therapy (BNCT)
cerebrospinal fluid (CSF) circulation
brain tumor
melanoma model rat
ex vivo imaging
matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI)
Online Access:https://www.mdpi.com/2075-1729/12/11/1786

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https://www.mdpi.com/2075-1729/12/11/1786

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