Antidepressant effects of 70% ethanolic extract of Lonicerae japonicae flos and it contained chlorogenic acid via upregulation of BDNF-TrkB pathway in the hippocampus of mice
Lonicera japonica flos (LJF) is a common clinical herb with outstanding medicinal and nutritional value. This study aimed to evaluate the antidepressant effects of LJF’s active extract and compound chlorogenic acid (CGA) around brain-derived neurotrophic factor(BDNF)-tropomyosin receptor kinase B (T...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923023002216 |
| _version_ | 1827753345303969792 |
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| author | Lingyu Qin Junming Wang Xiaohui Wu Lingling Song Yueyue Zhang Mingzhu Gong Yanmei Wang Bingyin Li |
| author_facet | Lingyu Qin Junming Wang Xiaohui Wu Lingling Song Yueyue Zhang Mingzhu Gong Yanmei Wang Bingyin Li |
| author_sort | Lingyu Qin |
| collection | DOAJ |
| description | Lonicera japonica flos (LJF) is a common clinical herb with outstanding medicinal and nutritional value. This study aimed to evaluate the antidepressant effects of LJF’s active extract and compound chlorogenic acid (CGA) around brain-derived neurotrophic factor(BDNF)-tropomyosin receptor kinase B (TrkB) pathway. The results showed that LJF’s extracts and CGA had significant antidepressant effects, and the antidepressant effects of different extracts of LJF were highly positively correlated with the content of CGA (forced swimming test, r = 0.998; tail suspension test, r = 0.934). Moreover, LJF-70% ethanolic extract and CGA improved chronic unpredictable mild stress-induced depressive behavior, upregulated protein expression levels of BDNF and p-TrkB in the hippocampus, restored the damage of hippocampal neurons, and protected liver from damage. In summary, this study demonstrated for the first time that LJF-70% ethanolic extract was the active extract of LJF in antidepressant and CGA was its active compound, and the antidepressant mechanisms mainly involved the upregulation of BDNF-TrkB signaling pathway in the hippocampus of mice. |
| first_indexed | 2024-03-11T07:34:52Z |
| format | Article |
| id | doaj.art-603c3057b0924d62a14899f08c48b291 |
| institution | Directory Open Access Journal |
| issn | 1873-2747 |
| language | English |
| last_indexed | 2024-03-11T07:34:52Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj.art-603c3057b0924d62a14899f08c48b2912023-11-17T05:25:00ZengElsevierBrain Research Bulletin1873-27472023-11-01204110796Antidepressant effects of 70% ethanolic extract of Lonicerae japonicae flos and it contained chlorogenic acid via upregulation of BDNF-TrkB pathway in the hippocampus of miceLingyu Qin0Junming Wang1Xiaohui Wu2Lingling Song3Yueyue Zhang4Mingzhu Gong5Yanmei Wang6Bingyin Li7College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollege of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China; Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry, Henan University of Chinese Medicine, Zhengzhou 450046, China; Correspondence to: College of Pharmacy, Henan University of Chinese Medicine, 156 Jinshui East Road, Zhengzhou 450046, China.College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollege of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollege of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollege of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollege of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollege of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaLonicera japonica flos (LJF) is a common clinical herb with outstanding medicinal and nutritional value. This study aimed to evaluate the antidepressant effects of LJF’s active extract and compound chlorogenic acid (CGA) around brain-derived neurotrophic factor(BDNF)-tropomyosin receptor kinase B (TrkB) pathway. The results showed that LJF’s extracts and CGA had significant antidepressant effects, and the antidepressant effects of different extracts of LJF were highly positively correlated with the content of CGA (forced swimming test, r = 0.998; tail suspension test, r = 0.934). Moreover, LJF-70% ethanolic extract and CGA improved chronic unpredictable mild stress-induced depressive behavior, upregulated protein expression levels of BDNF and p-TrkB in the hippocampus, restored the damage of hippocampal neurons, and protected liver from damage. In summary, this study demonstrated for the first time that LJF-70% ethanolic extract was the active extract of LJF in antidepressant and CGA was its active compound, and the antidepressant mechanisms mainly involved the upregulation of BDNF-TrkB signaling pathway in the hippocampus of mice.http://www.sciencedirect.com/science/article/pii/S0361923023002216Ethanolic extract of Lonicerae japonicae flosThe antidepressant active extractChlorogenic acidThe key antidepressant active compoundBDNF-TrkB pathwayNeurological nutrition |
| spellingShingle | Lingyu Qin Junming Wang Xiaohui Wu Lingling Song Yueyue Zhang Mingzhu Gong Yanmei Wang Bingyin Li Antidepressant effects of 70% ethanolic extract of Lonicerae japonicae flos and it contained chlorogenic acid via upregulation of BDNF-TrkB pathway in the hippocampus of mice Brain Research Bulletin Ethanolic extract of Lonicerae japonicae flos The antidepressant active extract Chlorogenic acid The key antidepressant active compound BDNF-TrkB pathway Neurological nutrition |
| title | Antidepressant effects of 70% ethanolic extract of Lonicerae japonicae flos and it contained chlorogenic acid via upregulation of BDNF-TrkB pathway in the hippocampus of mice |
| title_full | Antidepressant effects of 70% ethanolic extract of Lonicerae japonicae flos and it contained chlorogenic acid via upregulation of BDNF-TrkB pathway in the hippocampus of mice |
| title_fullStr | Antidepressant effects of 70% ethanolic extract of Lonicerae japonicae flos and it contained chlorogenic acid via upregulation of BDNF-TrkB pathway in the hippocampus of mice |
| title_full_unstemmed | Antidepressant effects of 70% ethanolic extract of Lonicerae japonicae flos and it contained chlorogenic acid via upregulation of BDNF-TrkB pathway in the hippocampus of mice |
| title_short | Antidepressant effects of 70% ethanolic extract of Lonicerae japonicae flos and it contained chlorogenic acid via upregulation of BDNF-TrkB pathway in the hippocampus of mice |
| title_sort | antidepressant effects of 70 ethanolic extract of lonicerae japonicae flos and it contained chlorogenic acid via upregulation of bdnf trkb pathway in the hippocampus of mice |
| topic | Ethanolic extract of Lonicerae japonicae flos The antidepressant active extract Chlorogenic acid The key antidepressant active compound BDNF-TrkB pathway Neurological nutrition |
| url | http://www.sciencedirect.com/science/article/pii/S0361923023002216 |
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