Unique Features of the Gut Microbiome Characterized in Animal Models of Angelman Syndrome

Unique Features of the Gut Microbiome Characterized in Animal Models of Angelman Syndrome

ABSTRACT A large subset of patients with Angelman syndrome (AS) suffer from concurrent gastrointestinal (GI) issues, including constipation, poor feeding, and reflux. AS is caused by the loss of ubiquitin ligase E3A (UBE3A) gene expression in the brain. Clinical features of AS, which include develop...

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Main Authors: Ulrika Beitnere, Brayan Vilanova-Cuevas, Sarah G. Christian, Clint Taylor, Elizabeth L. Berg, Nycole A. Copping, Scott V. Dindot, Jill L. Silverman, Mélanie G. Gareau, David J. Segal
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:mSystems
Subjects:
Angelman syndrome
neurodevelopmental disorders
16S rRNA gene sequencing
gut-brain axis
microbiota
animal models
Online Access:https://journals.asm.org/doi/10.1128/msystems.00608-22

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https://journals.asm.org/doi/10.1128/msystems.00608-22

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