Peripheral blood mononuclear cells reactivity in recent-onset type I diabetes patients is directed against the leader peptide of preproinsulin, GAD65271-285 and GAD65431-450

Peripheral blood mononuclear cells reactivity in recent-onset type I diabetes patients is directed against the leader peptide of preproinsulin, GAD65271-285 and GAD65431-450

IntroductionT cell reactivity against pancreatic autoantigens is considered one of the main contributors to the destruction of insulin-producing cells in type 1 diabetes (T1D). Over the years, peptide epitopes derived from these autoantigens have been described in NOD mice and in both HLA class II t...

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Bibliographic Details
Main Authors: Rita D. Jores, Davide Baldera, Enrico Schirru, Sandro Muntoni, Rossano Rossino, Maria F. Manchinu, Maria F. Marongiu, Cristian A. Caria, Carlo Ripoli, Maria R. Ricciardi, Francesco Cucca, Mauro Congia
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
children
type 1 diabetes mellitus
epitopes
glutamate decarboxylase
preproinsulin
human leukocyte antigen
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1130019/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1130019/full

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