Metronidazole and Secnidazole Carbamates: Synthesis, Antiprotozoal Activity, and Molecular Dynamics Studies

Metronidazole and Secnidazole Carbamates: Synthesis, Antiprotozoal Activity, and Molecular Dynamics Studies

We prepared a series of 10 carbamates derivatives based on two common antiprotozoal drugs: metronidazole (<b>1</b>&#8722;<b>5</b>) and secnidazole (<b>6</b>&#8722;<b>10</b>). The compounds were tested in vitro against a set of two amitochondria...

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Bibliographic Details
Main Authors: Genaro Rocha-Garduño, Norma Angélica Hernández-Martínez, Blanca Colín-Lozano, Samuel Estrada-Soto, Emanuel Hernández-Núñez, Fernando Daniel Prieto-Martínez, José L. Medina-Franco, Juan Bautista Chale-Dzul, Rosa Moo-Puc, Gabriel Navarrete-Vázquez
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Molecules
Subjects:
carbamates
metronidazole
molecular dynamics
parasites
secnidazole
Online Access:https://www.mdpi.com/1420-3049/25/4/793

Internet

https://www.mdpi.com/1420-3049/25/4/793

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