Functionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinol

Abstract Cannabinol (CBN), an incompletely understood metabolite for ∆9-tetrahydrocannabinol, has been suggested as an analgesic. CBN interacts with endocannabinoid (CB) receptors, but is also reported to interact with non-CB targets, including various ion channels. We assessed CBN effects on voltag...

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Bibliographic Details
Main Authors: Mohammad-Reza Ghovanloo, Philip R. Effraim, Sidharth Tyagi, Peng Zhao, Sulayman D. Dib-Hajj, Stephen G. Waxman
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-05781-x