Functionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinol
Abstract Cannabinol (CBN), an incompletely understood metabolite for ∆9-tetrahydrocannabinol, has been suggested as an analgesic. CBN interacts with endocannabinoid (CB) receptors, but is also reported to interact with non-CB targets, including various ion channels. We assessed CBN effects on voltag...
Main Authors: | Mohammad-Reza Ghovanloo, Philip R. Effraim, Sidharth Tyagi, Peng Zhao, Sulayman D. Dib-Hajj, Stephen G. Waxman |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2024-01-01
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Series: | Communications Biology |
Online Access: | https://doi.org/10.1038/s42003-024-05781-x |
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