Inhibition of Plasmepsin V Activity Blocks Plasmodium falciparum Gametocytogenesis and Transmission to Mosquitoes

Summary: Plasmodium falciparum gametocytes infect mosquitoes and are responsible for malaria transmission. New interventions that block transmission could accelerate malaria elimination. Gametocytes develop within erythrocytes and activate protein export pathways that remodel the host cell. Plasmeps...

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Bibliographic Details
Main Authors: Charlie Jennison, Leonardo Lucantoni, Matthew T. O’Neill, Robyn McConville, Sara M. Erickson, Alan F. Cowman, Brad E. Sleebs, Vicky M. Avery, Justin A. Boddey
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719315645