Coronary Artery Spasm: The Interplay Between Endothelial Dysfunction and Vascular Smooth Muscle Cell Hyperreactivity
Patients with angina pectoris, the cardinal symptom of myocardial ischaemia, yet without significant flow-limiting epicardial artery stenosis represent a diagnostic and therapeutic challenge. Coronary artery spasm (CAS) is an established cause for anginal chest pain in patients with angiographically...
| Váldodahkkit: | , , , , , |
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| Materiálatiipa: | Artihkal |
| Giella: | English |
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Radcliffe Medical Media
2020-03-01
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| Ráidu: | European Cardiology Review |
| Liŋkkat: | https://www.ecrjournal.com/articleindex/ecr.2019.20 |
| _version_ | 1826933310135205888 |
|---|---|
| author | Astrid Hubert Andreas Seitz Valeria Martínez Pereyra Raffi Bekeredjian Udo Sechtem Peter Ong |
| author_facet | Astrid Hubert Andreas Seitz Valeria Martínez Pereyra Raffi Bekeredjian Udo Sechtem Peter Ong |
| author_sort | Astrid Hubert |
| collection | DOAJ |
| description | Patients with angina pectoris, the cardinal symptom of myocardial ischaemia, yet without significant flow-limiting epicardial artery stenosis represent a diagnostic and therapeutic challenge. Coronary artery spasm (CAS) is an established cause for anginal chest pain in patients with angiographically unobstructed coronary arteries. CAS may occur at the epicardial level and/or in the microvasculature. Although the underlying pathophysiological mechanisms of CAS are still largely unclear, endothelial dysfunction and vascular smooth muscle cell (VSMC) hyperreactivity seem to be involved as major players, although their contribution to induce CAS is still seen as controversial. This article will look at the role and possible mechanistic interplay between an impaired endothelial and VSMC function in the pathogenesis of CAS. |
| first_indexed | 2024-03-07T17:41:57Z |
| format | Article |
| id | doaj.art-6044c2c127c44d8d9732f70601633be7 |
| institution | Directory Open Access Journal |
| issn | 1758-3756 1758-3764 |
| language | English |
| last_indexed | 2025-02-17T17:29:09Z |
| publishDate | 2020-03-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | European Cardiology Review |
| spelling | doaj.art-6044c2c127c44d8d9732f70601633be72024-12-14T16:01:51ZengRadcliffe Medical MediaEuropean Cardiology Review1758-37561758-37642020-03-011510.15420/ecr.2019.20Coronary Artery Spasm: The Interplay Between Endothelial Dysfunction and Vascular Smooth Muscle Cell HyperreactivityAstrid Hubert0Andreas Seitz1Valeria Martínez Pereyra2Raffi Bekeredjian3Udo Sechtem4Peter Ong5Robert-Bosch-Krankenhaus, Department of Cardiology, Stuttgart, GermanyRobert-Bosch-Krankenhaus, Department of Cardiology, Stuttgart, GermanyRobert-Bosch-Krankenhaus, Department of Cardiology, Stuttgart, GermanyRobert-Bosch-Krankenhaus, Department of Cardiology, Stuttgart, GermanyRobert-Bosch-Krankenhaus, Department of Cardiology, Stuttgart, GermanyRobert-Bosch-Krankenhaus, Department of Cardiology, Stuttgart, GermanyPatients with angina pectoris, the cardinal symptom of myocardial ischaemia, yet without significant flow-limiting epicardial artery stenosis represent a diagnostic and therapeutic challenge. Coronary artery spasm (CAS) is an established cause for anginal chest pain in patients with angiographically unobstructed coronary arteries. CAS may occur at the epicardial level and/or in the microvasculature. Although the underlying pathophysiological mechanisms of CAS are still largely unclear, endothelial dysfunction and vascular smooth muscle cell (VSMC) hyperreactivity seem to be involved as major players, although their contribution to induce CAS is still seen as controversial. This article will look at the role and possible mechanistic interplay between an impaired endothelial and VSMC function in the pathogenesis of CAS.https://www.ecrjournal.com/articleindex/ecr.2019.20 |
| spellingShingle | Astrid Hubert Andreas Seitz Valeria Martínez Pereyra Raffi Bekeredjian Udo Sechtem Peter Ong Coronary Artery Spasm: The Interplay Between Endothelial Dysfunction and Vascular Smooth Muscle Cell Hyperreactivity European Cardiology Review |
| title | Coronary Artery Spasm: The Interplay Between Endothelial Dysfunction and Vascular Smooth Muscle Cell Hyperreactivity |
| title_full | Coronary Artery Spasm: The Interplay Between Endothelial Dysfunction and Vascular Smooth Muscle Cell Hyperreactivity |
| title_fullStr | Coronary Artery Spasm: The Interplay Between Endothelial Dysfunction and Vascular Smooth Muscle Cell Hyperreactivity |
| title_full_unstemmed | Coronary Artery Spasm: The Interplay Between Endothelial Dysfunction and Vascular Smooth Muscle Cell Hyperreactivity |
| title_short | Coronary Artery Spasm: The Interplay Between Endothelial Dysfunction and Vascular Smooth Muscle Cell Hyperreactivity |
| title_sort | coronary artery spasm the interplay between endothelial dysfunction and vascular smooth muscle cell hyperreactivity |
| url | https://www.ecrjournal.com/articleindex/ecr.2019.20 |
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