Epitope flexibility and dynamic footprint revealed by molecular dynamics of a pMHC-TCR complex.

Epitope flexibility and dynamic footprint revealed by molecular dynamics of a pMHC-TCR complex.

The crystal structures of unliganded and liganded pMHC molecules provide a structural basis for TCR recognition yet they represent 'snapshots' and offer limited insight into dynamics that may be important for interaction and T cell activation. MHC molecules HLA-B*3501 and HLA-B*3508 both b...

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Bibliographic Details
Main Authors: Cyril F Reboul, Grischa R Meyer, Benjamin T Porebski, Natalie A Borg, Ashley M Buckle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3297556?pdf=render

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http://europepmc.org/articles/PMC3297556?pdf=render

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