GADD34 Ablation Exacerbates Retinal Degeneration in P23H RHO Mice

GADD34 Ablation Exacerbates Retinal Degeneration in P23H RHO Mice

The UPR is sustainably activated in degenerating retinas, leading to translational inhibition via p-eIF2α. Recent findings have demonstrated that ablation of growth arrest and DNA damage-inducible protein 34 (GADD34), a protein phosphatase 1 regulatory subunit permitting translational machinery oper...

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Bibliographic Details
Main Authors: Irina V. Saltykova, Assylbek Zhylkibayev, Oleg S. Gorbatyuk, Marina S. Gorbatyuk
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
retinal degeneration
unfolded protein response
integrated stress response
p-eIF2α
translational attenuation
GADD34
Online Access:https://www.mdpi.com/1422-0067/23/22/13748

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https://www.mdpi.com/1422-0067/23/22/13748

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