BMP3 suppresses colon tumorigenesis via ActRIIB/SMAD2-dependent and TAK1/JNK signaling pathways

BMP3 suppresses colon tumorigenesis via ActRIIB/SMAD2-dependent and TAK1/JNK signaling pathways

Abstract Background BMP3 gene is often found hypermethylated and hence inactivated in several types of cancers including colorectal cancer (CRC), indicating that it has a suppressor role in carcinogenesis. Though BMP3 is a reliable biomarker for screening CRC, the molecular mechanism of BMP3 in carc...

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Bibliographic Details
Main Authors: Jialing Wen, Xianglin Liu, Yan Qi, Feng Niu, Zhitong Niu, Wenjing Geng, Zhaowei Zou, Renli Huang, Jianping Wang, Hongzhi Zou
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
BMP3
Inhibitor
ActRIIB
SMAD2
Colorectal cancer
Online Access:http://link.springer.com/article/10.1186/s13046-019-1435-1

Internet

http://link.springer.com/article/10.1186/s13046-019-1435-1

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