Environmental Enrichment Reverses Histone Methylation Changes in the Aged Hippocampus and Restores Age-Related Memory Deficits

Environmental Enrichment Reverses Histone Methylation Changes in the Aged Hippocampus and Restores Age-Related Memory Deficits

A decline in long-term memory (LTM) formation is a common feature of the normal aging process, which corresponds with abnormal expression of memory-related genes in the aged hippocampus. Epigenetic modulation of chromatin structure is required for proper transcriptional control of genes, such as the...

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Bibliographic Details
Main Authors: Sarah J. Morse, Anderson A. Butler, Robin L. Davis, Ian J. Soller, Farah D. Lubin
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Biology
Subjects:
epigenetics
histone acetylation
gene expression
memory
chromatin remodeling
hippocampus
methyltransferases
demethylases
Online Access:http://www.mdpi.com/2079-7737/4/2/298

Internet

http://www.mdpi.com/2079-7737/4/2/298

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