Unraveling the Genotype‐Phenotype Relationship in Hypertrophic Cardiomyopathy: Obesity‐Related Cardiac Defects as a Major Disease Modifier

Unraveling the Genotype‐Phenotype Relationship in Hypertrophic Cardiomyopathy: Obesity‐Related Cardiac Defects as a Major Disease Modifier

Abstract Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy and is characterized by asymmetric septal thickening and diastolic dysfunction. More than 1500 mutations in genes encoding sarcomere proteins are associated with HCM. However, the genotype‐phenotype relationship i...

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Bibliographic Details
Main Authors: Edgar E. Nollet, B. Daan Westenbrink, Rudolf A. de Boer, Diederik W. D. Kuster, Jolanda van der Velden
Format: Article
Language:English
Published: Wiley 2020-11-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
disease modifiers
hypertrophic cardiomyopathy
obesity
pathophysiology
type 2 diabetes mellitus
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.120.018641

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https://www.ahajournals.org/doi/10.1161/JAHA.120.018641

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