Use of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilization.

Use of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilization.

Current limitations of chemotherapy include toxicity on healthy tissues and multidrug resistance of malignant cells. A number of recent anti-cancer strategies aim at targeting the mitochondrial apoptotic machinery to induce tumor cell death. In this study, we set up protocols to purify functional mi...

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Bibliographic Details
Main Authors: Nelly Buron, Mathieu Porceddu, Magali Brabant, Diana Desgué, Cindy Racoeur, Myriam Lassalle, Christine Péchoux, Pierre Rustin, Etienne Jacotot, Annie Borgne-Sanchez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20360986/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20360986/pdf/?tool=EBI

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