Oral polio revaccination is associated with changes in gut and upper respiratory microbiomes of infants

Oral polio revaccination is associated with changes in gut and upper respiratory microbiomes of infants

After the eradication of polio infection, the plan is to phase-out the live-attenuated oral polio vaccine (OPV). Considering the protective non-specific effects (NSE) of OPV on unrelated pathogens, the withdrawal may impact child health negatively. Within a cluster-randomized trial, we carried out 1...

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Bibliographic Details
Main Authors: Márcia Melo Medeiros, Anna Cäcilia Ingham, Line Møller Nanque, Claudino Correia, Marc Stegger, Paal Skyt Andersen, Ane Baerent Fisker, Christine Stabell Benn, Miguel Lanaspa, Henrique Silveira, Patrícia Abrantes
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Microbiology
Subjects:
OPV-revaccination
non-specific effects
16S rRNA deep sequencing
bacterial microbiota
healthier microbiome composition
upper respiratory microbiome
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.1016220/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.1016220/full

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