Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles

Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles

Self-assembling protein nanoparticles (NPs) presenting BG505 envelope (Env) trimers can elicit tier 2 HIV-1-neutralizing antibody (NAb) responses more effectively than soluble trimers. In the present study, monoclonal NAbs were isolated from previously immunized mice and rabbits for structural and f...

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Bibliographic Details
Main Authors: Sonu Kumar, Xiaohe Lin, Timothy Ngo, Benjamin Shapero, Cindy Sou, Joel D. Allen, Jeffrey Copps, Lei Zhang, Gabriel Ozorowski, Linling He, Max Crispin, Andrew B. Ward, Ian A. Wilson, Jiang Zhu
Format: Article
Language:English
Published: American Society for Microbiology 2021-06-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.00429-21

Internet

https://journals.asm.org/doi/10.1128/mBio.00429-21

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