Dynamic changes in immune cell populations by AXL kinase targeting diminish liver inflammation and fibrosis in experimental MASH

Dynamic changes in immune cell populations by AXL kinase targeting diminish liver inflammation and fibrosis in experimental MASH

Background and aimsMetabolic dysfunction-associated steatohepatitis (MASH) is a significant health concern with limited treatment options. AXL, a receptor tyrosine kinase activated by the GAS6 ligand, promotes MASH through activation of hepatic stellate cells and inflammatory macrophages. This study...

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Bibliographic Details
Main Authors: Sturla Magnus Grøndal, Anna Tutusaus, Loreto Boix, Maria Reig, Magnus Blø, Linn Hodneland, Gro Gausdal, Akil Jackson, Pablo Garcia de Frutos, James Bradley Lorens, Albert Morales, Montserrat Marí
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-05-01
Series:Frontiers in Immunology
Subjects:
TAM receptors
mass cytometry
MERTK
GAS6
liver fibrosis
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1400553/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1400553/full

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