Structure of Helicobacter pylori dihydroneopterin aldolase suggests a fragment-based strategy for isozyme-specific inhibitor design

Structure of Helicobacter pylori dihydroneopterin aldolase suggests a fragment-based strategy for isozyme-specific inhibitor design

Dihydroneopterin aldolase (DHNA) is essential for folate biosynthesis in microorganisms. Without a counterpart in mammals, DHNA is an attractive target for antimicrobial agents. Helicobacter pylori infection occurs in human stomach of over 50% of the world population, but first-line therapies for th...

Full description

Bibliographic Details
Main Authors: Gary X. Shaw, Lixin Fan, Scott Cherry, Genbin Shi, Joseph E. Tropea, Xinhua Ji
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Current Research in Structural Biology
Subjects:
Dihydroneopterin aldolase
Folate biosynthesis
Helicobacter pylori
Antibiotic
Fragment-based drug discovery
Online Access:http://www.sciencedirect.com/science/article/pii/S2665928X23000016

Internet

http://www.sciencedirect.com/science/article/pii/S2665928X23000016

Similar Items