Structure of Helicobacter pylori dihydroneopterin aldolase suggests a fragment-based strategy for isozyme-specific inhibitor design
Dihydroneopterin aldolase (DHNA) is essential for folate biosynthesis in microorganisms. Without a counterpart in mammals, DHNA is an attractive target for antimicrobial agents. Helicobacter pylori infection occurs in human stomach of over 50% of the world population, but first-line therapies for th...
Main Authors: | Gary X. Shaw, Lixin Fan, Scott Cherry, Genbin Shi, Joseph E. Tropea, Xinhua Ji |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2023-01-01
|
Series: | Current Research in Structural Biology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2665928X23000016 |
Similar Items
-
Oxidative stress and immune cell activation quantification in sepsis and non-sepsis critical care patients by neopterin/7,8-dihydroneopterin analysis
by: Baxter-Parker Gregory, et al.
Published: (2020-05-01) -
Infeksi Helicobacter pylori /
by: 558487 Sabiha Pit
Published: (2005) -
Role of Helicobacter pylori in Rosacea
by: Nazan EMİROĞLU, et al.
Published: (2018-01-01) -
Helicobacter Pylori Positivity in Patients with Hyperemesis Gravidarum
by: Emel Ebru Özçimen, et al.
Published: (2006-12-01) -
Tratamiento de la infección por Helicobacter pylori: Comentario al respecto
by: Noel Padrón Pérez, et al.
Published: (1999-12-01)