Synthesis and biological profile of 2,3-dihydro[1,3]thiazolo[4,5-b]pyridines, a novel class of acyl-ACP thioesterase inhibitors

Synthesis and biological profile of 2,3-dihydro[1,3]thiazolo[4,5-b]pyridines, a novel class of acyl-ACP thioesterase inhibitors

The present work covers novel herbicidal lead structures that contain a 2,3-dihydro[1,3]thiazolo[4,5-b]pyridine scaffold as structural key feature carrying a substituted phenyl side chain. These new compounds show good acyl-ACP thioesterase inhibition in line with strong herbicidal activity against...

Full description

Bibliographic Details
Main Authors: Jens Frackenpohl, David M. Barber, Guido Bojack, Birgit Bollenbach-Wahl, Ralf Braun, Rahel Getachew, Sabine Hohmann, Kwang-Yoon Ko, Karoline Kurowski, Bernd Laber, Rebecca L. Mattison, Thomas Müller, Anna M. Reingruber, Dirk Schmutzler, Andrea Svejda
Format: Article
Language:English
Published: Beilstein-Institut 2024-03-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
2,3-dihydro[1,3]thiazolo[4,5-b]pyridine
acyl-acp thioesterase
bioisostere
herbicide
heterocycle
Online Access:https://doi.org/10.3762/bjoc.20.46

Internet

https://doi.org/10.3762/bjoc.20.46

Similar Items