UBR4/POE facilitates secretory trafficking to maintain circadian clock synchrony

UBR4/POE facilitates secretory trafficking to maintain circadian clock synchrony

Although ubiquitin ligases are known to control clock protein degradation, their other roles in clock neurons are unclear. Here the authors report that UBR4 promotes export of neuropeptides from the Golgi for axonal trafficking, which is important for circadian clock synchrony in mice and flies.

Bibliographic Details
Main Authors: Sara Hegazi, Arthur H. Cheng, Joshua J. Krupp, Takafumi Tasaki, Jiashu Liu, Daniel A. Szulc, Harrod H. Ling, Julian Rios Garcia, Shavanie Seecharran, Tayebeh Basiri, Mehdi Amiri, Zobia Anwar, Safa Ahmad, Kamar Nayal, Nahum Sonenberg, Bao-Hua Liu, Hai-Ling Margaret Cheng, Joel D. Levine, Hai-Ying Mary Cheng
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-29244-1

Internet

https://doi.org/10.1038/s41467-022-29244-1

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