Pregnenolone Inhibits Osteoclast Differentiation and Protects Against Lipopolysaccharide-Induced Inflammatory Bone Destruction and Ovariectomy-Induced Bone Loss

Pregnenolone Inhibits Osteoclast Differentiation and Protects Against Lipopolysaccharide-Induced Inflammatory Bone Destruction and Ovariectomy-Induced Bone Loss

Osteolytic bone disease is characterized by excessive osteoclast bone resorption leading to increased skeletal fragility and fracture risk. Multinucleated osteoclasts formed through the fusion of mononuclear precursors are the principle cell capable of bone resorption. Pregnenolone (Preg) is the gra...

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Bibliographic Details
Main Authors: Xiaochen Sun, Chenxi Zhang, Huan Guo, Jiao Chen, Yali Tao, Fuxiao Wang, Xixi Lin, Qian Liu, Li Su, An Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
LPS (lipopolysaccharide)
OVX model
osteoclast (OCs)
ERK
RANKL (receptor activator of nuclear factor kappa-B ligand)
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00360/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00360/full

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