PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity

PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity

Regulated proinsulin biosynthesis, disulfide bond formation and ER redox homeostasis are essential to prevent Type two diabetes. In ß cells, protein disulfide isomerase A1 (PDIA1/P4HB), the most abundant ER oxidoreductase of over 17 members, can interact with proinsulin to influence disulfide matura...

Full description

Bibliographic Details
Main Authors: Insook Jang, Anita Pottekat, Juthakorn Poothong, Jing Yong, Jacqueline Lagunas-Acosta, Adriana Charbono, Zhouji Chen, Donalyn L Scheuner, Ming Liu, Pamela Itkin-Ansari, Peter Arvan, Randal J Kaufman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
PDIA1
proinsulin maturation
beta cell function
glucose homeostasis
disulfide bond formation
type 2 diabetes
Online Access:https://elifesciences.org/articles/44528

Internet

https://elifesciences.org/articles/44528

Similar Items