Novel idebenone derivatives attenuated oxidative stress injury and myocardial damage

Novel idebenone derivatives attenuated oxidative stress injury and myocardial damage

Oxidative stress-induced cardiomyocyte apoptosis was the primary causative factor of cardiovascular disease (CVD). However, the existing therapy drugs for oxidative stress were much less investigated, which underlined the necessity for new drug discovery and development. Herein, we aimed to synthesi...

Full description

Bibliographic Details
Main Authors: Yuwei Peng, Yishan Guo, Xinyi Yang, Yulan Liu, Xun Xu, Junhong Chen, Xueyi Liu, Zhenrou Xie, Zhiqiang Yu, Dudu Wu, Zhi Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Chemistry
Subjects:
idebenone derivative
oxidative stress
HO-1 protein
Bax/Bcl-2 protein
cardiovascular disease
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2025.1544616/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2025.1544616/full

Similar Items