An HIV Vaccine Protective Allele in FCGR2C Associates With Increased Odds of Perinatal HIV Acquisition

An HIV Vaccine Protective Allele in FCGR2C Associates With Increased Odds of Perinatal HIV Acquisition

In the Thai RV144 HIV-1 vaccine trial, a three-variant haplotype within the Fc gamma receptor 2C gene (FCGR2C) reduced the risk of HIV-1 acquisition. A follow-on trial, HVTN702, of a similar vaccine candidate found no efficacy in South Africa, where the predominant population is polymorphic for only...

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Bibliographic Details
Main Authors: Joy Ebonwu, Ria Lassaunière, Maria Paximadis, Mark Goosen, Renate Strehlau, Glenda E. Gray, Louise Kuhn, Caroline T. Tiemessen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
Fc gamma receptor
FCGR2C
genetic variant
polymorphism
gene copy number
perinatal HIV-1 acquisition
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.760571/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.760571/full

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