Nitrite Promotes ROS Production to Potentiate Cefoperazone-Sulbactam-Mediated Elimination to Lab-Evolved and Clinical-Evolved Pseudomonas aeruginosa

Nitrite Promotes ROS Production to Potentiate Cefoperazone-Sulbactam-Mediated Elimination to Lab-Evolved and Clinical-Evolved Pseudomonas aeruginosa

ABSTRACT Cefoperazone-sulbactam (SCF)-resistant Pseudomonas aeruginosa poses a big challenge in the use of SCF to treat infection caused by the pathogen. We have recently shown exogenous nitrite-enabled killing of naturally and artificially evolved Pseudomonas aeruginosa strains (AP-RCLIN-EVO and AP...

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Bibliographic Details
Main Authors: Su-fang Kuang, Xia Li, Ding-Yun Feng, Wen-Bin Wu, Hui Li, Bo Peng, Xuan-xian Peng, Zhuang-gui Chen, Tian-tuo Zhang
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:Microbiology Spectrum
Subjects:
Pseudomonas aeruginosa
antibiotic resistance
cefoperazone-sulbactam
electron transport chain
nitrite
reprogramming metabolomics
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02327-21

Internet

https://journals.asm.org/doi/10.1128/spectrum.02327-21

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