Herb-drug interaction: Effect of sinapic acid on the pharmacokinetics of dasatinib in rats

Herb-drug interaction: Effect of sinapic acid on the pharmacokinetics of dasatinib in rats

Dasatinib (DAS) is a narrow therapeutic index drug and novel oral multitarget inhibitor of tyrosine kinase and approved for the first-line therapy for chronic myelogenous leukemia (CML) and Philadelphia chromosome (Ph + ) acute lymphoblastic leukemia (ALL). DAS, a known potent substrate of cytochrom...

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Bibliographic Details
Main Authors: Mudassar Shahid, Ajaz Ahmad, Mohammad Raish, Yousef A Bin Jardan, Khalid M. Alkharfy, Abdul Ahad, Mohd Abul Kalam, Mushtaq Ahmad Ansari, Muzaffer Iqbal, Naushad Ali, Fahad I. Al-Jenoobi
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Saudi Pharmaceutical Journal
Subjects:
Herb drug interactions
Sinapic acid
Dasatinib
Pgp/MDR1
BCPR/ABCG2
CYP3A2
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016423003146

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http://www.sciencedirect.com/science/article/pii/S1319016423003146

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