Autoantibodies against NMDAR subunit NR1 disappear from blood upon anesthesia

Autoantibodies against NMDAR subunit NR1 disappear from blood upon anesthesia

Anesthetics penetrate the blood-brain-barrier (BBB) and - as confirmed preclinically – transiently disrupt it. An analogous consequence in humans has remained unproven. In mice, we previously reported that upon BBB dysfunction, the brain acts as ‘immunoprecipitator’ of autoantibodies against N-methy...

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Bibliographic Details
Main Authors: Johannes Teller, Carolin Jung, Justus B.H. Wilke, Svea-Dorothée Schimmelpfennig, Martin Hindermann, Lukas Hinken, Maria M. Gabriel, Christine Fegbeutel, Andreas Schäfer, Hans Laser, Ralf Lichtinghagen, Hans Worthmann, Karin Weissenborn, Hannelore Ehrenreich
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Blood-brain-barrier opening
BBB breakdown
Seroprevalence
Serum proteins
Immunoglobulin class
Cardiac surgery
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354622000849

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http://www.sciencedirect.com/science/article/pii/S2666354622000849

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