Self-assembling Gn head ferritin nanoparticle vaccine provides full protection from lethal challenge of Dabie bandavirus in aged ferrets

Self-assembling Gn head ferritin nanoparticle vaccine provides full protection from lethal challenge of Dabie bandavirus in aged ferrets

ABSTRACT Dabie bandavirus (DBV), previously known as severe fever with thrombocytopenia syndrome (SFTS) virus, induces a characteristic thrombocytopenia with a mortality rate ranging from 12% to as high as 30%. The sero-prevalence of DBV in healthy people is not significantly different among age gro...

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Bibliographic Details
Main Authors: Dokyun Kim, Eunha Kim, Semi Kim, Youseung Chung, Chih-Jen Lai, Inho Cha, Sung-Dong Cho, Yunseo Choi, Xinghong Dai, Stephanie Kim, Seokmin Kang, Mi-Jeong Kwak, Ziyi Liu, Younho Choi, Su-Hyung Park, Young Ki Choi, Jae U. Jung
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
Dabie bandavirus
nanoparticle
tick-borne pathogens
vaccine
ferret model
Online Access:https://journals.asm.org/doi/10.1128/mbio.01868-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01868-23

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