Comparative analysis of gene expression between mice and humans in acetaminophen-induced liver injury by integrating bioinformatics analysis

Comparative analysis of gene expression between mice and humans in acetaminophen-induced liver injury by integrating bioinformatics analysis

Abstract Objective Mice are routinely utilized as animal models of drug-induced liver injury (DILI), however, there are significant differences in the pathogenesis between mice and humans. This study aimed to compare gene expression between humans and mice in acetaminophen (APAP)-induced liver injur...

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Bibliographic Details
Main Authors: Shanmin Zhao, Yan Feng, Jingyuan Zhang, Qianqian Zhang, Junyang Wang, Shufang Cui
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Medical Genomics
Subjects:
Gene expression
Mouse and human
Acetaminophen-induced liver injury
Bioinformatics analysis
Online Access:https://doi.org/10.1186/s12920-024-01848-0

Internet

https://doi.org/10.1186/s12920-024-01848-0

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