Conformational Stability of the N-Terminal Region of MDM2

Conformational Stability of the N-Terminal Region of MDM2

MDM2 is an E3 ubiquitin ligase which is crucial for the degradation and inhibition of the key tumor-suppressor protein p53. In this work, we explored the stability and the conformational features of the N-terminal region of MDM2 (N-MDM2), through which it binds to the p53 protein as well as other pr...

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Bibliographic Details
Main Authors: Bruno Rizzuti, Olga Abian, Adrián Velazquez-Campoy, José L. Neira
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Molecules
Subjects:
MDM2
intrinsically disordered protein
conformational stability
circular dichroism
fluorescence
differential scanning calorimetry
Online Access:https://www.mdpi.com/1420-3049/28/22/7578

Internet

https://www.mdpi.com/1420-3049/28/22/7578

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