Genomic Profiling of Biliary Tract Cancer Cell Lines Reveals Molecular Subtypes and Actionable Drug Targets

Genomic Profiling of Biliary Tract Cancer Cell Lines Reveals Molecular Subtypes and Actionable Drug Targets

Summary: Biliary tract cancers (BTCs) currently have no approved targeted therapies. Although genomic profiling of primary BTCs has identified multiple potential drug targets, accurate models are needed for their evaluation. Genomic profiling of 22 BTC cell lines revealed they harbor similar mutatio...

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Bibliographic Details
Main Authors: David K. Lau, Dmitri Mouradov, Wiphawan Wasenang, Ian Y. Luk, Cameron M. Scott, David S. Williams, Yvonne H. Yeung, Temduang Limpaiboon, George F. Iatropoulos, Laura J. Jenkins, Camilla M. Reehorst, Fiona Chionh, Mehrdad Nikfarjam, Daniel Croagh, Amardeep S. Dhillon, Andrew J. Weickhardt, Toshihide Muramatsu, Yoshimasa Saito, Niall C. Tebbutt, Oliver M. Sieber, John M. Mariadason
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004219304249

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http://www.sciencedirect.com/science/article/pii/S2589004219304249

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