Disruption in the regulation of casein kinase 2 in circadian rhythm leads to pathological states: cancer, diabetes and neurodegenerative disorders

Disruption in the regulation of casein kinase 2 in circadian rhythm leads to pathological states: cancer, diabetes and neurodegenerative disorders

IntroductionCircadian rhythm maintains the sleep–wake cycle in biological systems. Various biological activities are regulated and modulated by the circadian rhythm, disruption of which can result in onset of diseases. Robust rhythms of phosphorylation profiles and abundances of PERIOD (PER) protein...

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Bibliographic Details
Main Authors: Md. Zubbair Malik, Mohammed Dashti, Yasmin Fatima, Arshad Channanath, Sumi Elsa John, R. K. Brojen Singh, Fahd Al-Mulla, Thangavel Alphonse Thanaraj
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
circadian rhythm
PER protein
molecular noise
cellular state
mathematical modeling
pathological states
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1217992/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2023.1217992/full

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