Enhanced Nerve Regeneration by Exosomes Secreted by Adipose-Derived Stem Cells with or without FK506 Stimulation

Enhanced Nerve Regeneration by Exosomes Secreted by Adipose-Derived Stem Cells with or without FK506 Stimulation

Exosomes secreted by adipose-derived stem cells (ADSC-exo) reportedly improve nerve regeneration after peripheral nerve injury. Herein, we investigated whether pretreatment of ADSCs with FK506, an immunosuppressive drug that enhances nerve regeneration, could secret exosomes (ADSC-F-exo) that furthe...

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Bibliographic Details
Main Authors: Cheng-Shyuan Rau, Pao-Jen Kuo, Shao-Chun Wu, Lien-Hung Huang, Tsu-Hsiang Lu, Yi-Chan Wu, Chia-Jung Wu, Chia-Wei Lin, Chia-Wen Tsai, Ching-Hua Hsieh
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
sciatic nerve crush injury
peripheral nerve regeneration
exosome
adipose-derived stem cells (ADSC)
tacrolimus (FK506)
proteomic analysis
Online Access:https://www.mdpi.com/1422-0067/22/16/8545

Internet

https://www.mdpi.com/1422-0067/22/16/8545

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