Accelerated Degradation of Caspase-8 Protein Correlates with TRAIL Resistance in a DLD1 Human Colon Cancer Cell Line

Accelerated Degradation of Caspase-8 Protein Correlates with TRAIL Resistance in a DLD1 Human Colon Cancer Cell Line

The tumor-selective cytotoxic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) makes TRAIL an attractive candidate as an anticancer agent. However, resistance to TRAIL poses a challenge in anticancer therapy with TRAIL. Therefore, characterizing the mechanisms of resistance...

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Bibliographic Details
Main Authors: Lidong Zhang, Hongbo Zhu, Fuminori Teraishi, John J. Davis, Wei Guo, Zhen Fan, Bingliang Fang
Format: Article
Language:English
Published: Elsevier 2005-06-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
TRAIL
resistance
apoptosis
caspase-8
degradation
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605800806

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http://www.sciencedirect.com/science/article/pii/S1476558605800806

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