Wnt-Signaling Inhibitor Wnt-C59 Suppresses the Cytokine Upregulation in Multiple Organs of Lipopolysaccharide-Induced Endotoxemic Mice via Reducing the Interaction between β-Catenin and NF-κB

Wnt-Signaling Inhibitor Wnt-C59 Suppresses the Cytokine Upregulation in Multiple Organs of Lipopolysaccharide-Induced Endotoxemic Mice via Reducing the Interaction between β-Catenin and NF-κB

Sepsis is characterized by multiple-organ dysfunction caused by the dysregulated host response to infection. Until now, however, the role of the Wnt signaling has not been fully characterized in multiple organs during sepsis. This study assessed the suppressive effect of a Wnt signaling inhibitor, W...

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Bibliographic Details
Main Authors: Jaewoong Jang, Jaewon Song, Inae Sim, Young V. Kwon, Yoosik Yoon
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
Wnt-C59
Wnt
β-catenin
NF-κB
cytokine
endotoxemia
Online Access:https://www.mdpi.com/1422-0067/22/12/6249

Internet

https://www.mdpi.com/1422-0067/22/12/6249

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