Visualization of real-time receptor endocytosis in dopamine neurons enabled by NTSR1-Venus knock-in mice

Visualization of real-time receptor endocytosis in dopamine neurons enabled by NTSR1-Venus knock-in mice

Dopamine (DA) neurons are primarily concentrated in substantia nigra (SN) and ventral tegmental area (VTA). A subset of these neurons expresses the neurotensin receptor NTSR1 and its putative ligand neurotensin (Nts). NTSR1, a G protein-coupled receptor (GPCR), which classically activates Gαq/calciu...

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Bibliographic Details
Main Authors: Aliza T. Ehrlich, Pierre Couvineau, Selin Schamiloglu, Stefan Wojcik, Dillon Da Fonte, Amina Mezni, Mark von Zastrow, Kevin J. Bender, Michel Bouvier, Brigitte L. Kieffer
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
G protein-coupled receptor (GPCR)
brain
trafficking
neurotensin
PD149163
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.1076599/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2022.1076599/full

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