Palmatine ameliorates cisplatin-induced acute kidney injury through regulating Akt and NF-κB/MAPK pathways

Palmatine ameliorates cisplatin-induced acute kidney injury through regulating Akt and NF-κB/MAPK pathways

Cisplatin-induced acute kidney injury (CIAKI) is a major dose-limiting toxicity of cisplatin treatment. The mechanisms of CIAKI involve the production of inflammation, apoptosis and oxidative stress. Palmatine, an isoquinoline alkaloid has anti-inflammatory activity. Here, we investigated the protec...

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Bibliographic Details
Main Authors: Zhen Liu, Lvqian Guo, Xuan Zhu, Xinran Li, Wanshun Zhao, Peng Yu, Yuou Teng
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Arabian Journal of Chemistry
Subjects:
Palmatine
Cisplatin
Acute kidney injury
Inflammation
Oxidative stress
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535224001333

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http://www.sciencedirect.com/science/article/pii/S1878535224001333

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