Neutrophil extracellular trap-induced intermediate monocytes trigger macrophage activation syndrome in adult-onset Still’s disease

Neutrophil extracellular trap-induced intermediate monocytes trigger macrophage activation syndrome in adult-onset Still’s disease

Abstract Background Adult-onset Still’s disease (AOSD) is a systemic autoinflammatory disease characterized by innate immune system activation, with a high risk for macrophage activation syndrome (MAS). MAS development is associated with monocyte/macrophage activation and cytokine storm. Monocytes c...

Full description

Bibliographic Details
Main Authors: Jinchao Jia, Mengyan Wang, Yuning Ma, Jianfen Meng, Dehao Zhu, Xia Chen, Hui Shi, Yue Sun, Honglei Liu, Xiaobing Cheng, Yutong Su, Junna Ye, Huihui Chi, Tingting Liu, Zhuochao Zhou, Fan Wang, Longfang Chen, Da Yi, Yu Xiao, Chengde Yang, Jialin Teng, Qiongyi Hu
Format: Article
Language:English
Published: BMC 2023-12-01
Series:BMC Medicine
Subjects:
Adult-onset Still’s disease
Monocyte subset
CXCL10
Neutrophil extracellular traps
DNA sensing
Online Access:https://doi.org/10.1186/s12916-023-03231-9

Internet

https://doi.org/10.1186/s12916-023-03231-9

Similar Items