Evaluation of a Novel <i>FKS1</i> R1354H Mutation Associated with Caspofungin Resistance in <i>Candida auris</i> Using the CRISPR-Cas9 System

Evaluation of a Novel <i>FKS1</i> R1354H Mutation Associated with Caspofungin Resistance in <i>Candida auris</i> Using the CRISPR-Cas9 System

Outbreaks of invasive infections, with high mortality rates, caused by multidrug-resistant <i>Candida auris</i> have been reported worldwide. Although hotspot mutations in <i>FKS1</i> are an established cause of echinocandin resistance, the actual contribution of these mutati...

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Bibliographic Details
Main Authors: Maiko Kiyohara, Taiga Miyazaki, Michiyo Okamoto, Tatsuro Hirayama, Koichi Makimura, Hiroji Chibana, Nana Nakada, Yuya Ito, Makoto Sumiyoshi, Nobuyuki Ashizawa, Kazuaki Takeda, Naoki Iwanaga, Takahiro Takazono, Koichi Izumikawa, Katsunori Yanagihara, Shigeru Kohno, Hiroshi Mukae
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Journal of Fungi
Subjects:
<i>Candida auris</i>
echinocandin
caspofungin
antifungal resistance
<i>FKS1</i>
CRISPR-Cas9
Online Access:https://www.mdpi.com/2309-608X/9/5/529

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https://www.mdpi.com/2309-608X/9/5/529

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