Methylphenidate exposure induces dopamine neuron loss and activation of microglia in the basal ganglia of mice.

Methylphenidate exposure induces dopamine neuron loss and activation of microglia in the basal ganglia of mice.

BACKGROUND: Methylphenidate (MPH) is a psychostimulant that exerts its pharmacological effects via preferential blockade of the dopamine transporter (DAT) and the norepinephrine transporter (NET), resulting in increased monoamine levels in the synapse. Clinically, methylphenidate is prescribed for t...

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Bibliographic Details
Main Authors: Shankar Sadasivan, Brooks B Pond, Amar K Pani, Chunxu Qu, Yun Jiao, Richard J Smeyne
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3312333?pdf=render

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http://europepmc.org/articles/PMC3312333?pdf=render

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