Methylphenidate exposure induces dopamine neuron loss and activation of microglia in the basal ganglia of mice.

BACKGROUND: Methylphenidate (MPH) is a psychostimulant that exerts its pharmacological effects via preferential blockade of the dopamine transporter (DAT) and the norepinephrine transporter (NET), resulting in increased monoamine levels in the synapse. Clinically, methylphenidate is prescribed for t...

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Main Authors: Shankar Sadasivan, Brooks B Pond, Amar K Pani, Chunxu Qu, Yun Jiao, Richard J Smeyne
Format: Article
Jezik:English
Izdano: Public Library of Science (PLoS) 2012-01-01
Serija:PLoS ONE
Online dostop:http://europepmc.org/articles/PMC3312333?pdf=render